It is Patatin-like Phospholipase Domain-containing 3 Gene (PNPLA3)—All the Way
نویسندگان
چکیده
منابع مشابه
a meta-analysis of the association between the i148m variant of patatin-like phospholipase domain containing 3 gene and the presence of chronic hepatitis c
conclusions the current meta-analysis showed an association between frequency of gg genotype of pnpla3 and the risk of development of chc in various populations throughout the world. results five hospital-based case-control studies were included in the final analysis. the overall frequency of pnpla3 gene polymorphisms was 20.4% (205/1005) in chc and 10.23% (53/518) in controls. the summary odds...
متن کاملAssociation between patatin-like phospholipase domain-containing 3 gene (PNPLA3) polymorphism and overweight/obesity: a meta-analysis
Background: The patatin-like phospholipase domain-containing 3 (PNPLA3, rs738409) gene polymorphism has been implicated in susceptibility to overweight and obesity, but study results are still controversial. Objective: The present meta-analysis was performed to evaluate the relationship between PNPLA3 polymorphism and overweight/obesity among adults, children or adolescents. Methods: A literatu...
متن کاملcorrelation between patatin-like phospholipase domain-containing protein 3 gene polymorphisms and liver cirrhosis in a chinese han population with chronic hepatitis b
results the allele and genotype distributions of pnpla3 rs738409 and rs2281135 were not significantly different between the chb and lc groups. after segregation on the basis of sex, no significant correlation between pnpla3 (rs738409 and rs2281135) genotypes/alleles and liver cirrhosis was detected. moreover, none of the haplotypes in pnpla3 (rs738409 and rs2281135) was found to be statisticall...
متن کاملRole of Patatin-Like Phospholipase Domain-Containing 3 on Lipid-Induced Hepatic Steatosis and Insulin Resistance in Rats
UNLABELLED Genome-wide array studies have associated the patatin-like phospholipase domain-containing 3 (PNPLA3) gene polymorphisms with hepatic steatosis. However, it is unclear whether PNPLA3 functions as a lipase or a lipogenic enzyme and whether PNPLA3 is involved in the pathogenesis of hepatic insulin resistance. To address these questions we treated high-fat-fed rats with specific antisen...
متن کاملVertebrate patatin-like phospholipase domain-containing protein 4 (PNPLA4) genes and proteins: a gene with a role in retinol metabolism
At least eight families of mammalian patatinlike phospholipase domain-containing proteins (PNPLA) (E.C. 3.1.1.3) catalyse the hydrolysis of triglycerides, including PNPLA4 (alternatively PLPL4 or GS2), which also acts as a retinol transacylase and participates in retinolester metabolism in the body. Bioinformatic methods were used to predict the amino acid sequences, secondary and tertiary stru...
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ژورنال
عنوان ژورنال: Journal of Clinical and Experimental Hepatology
سال: 2012
ISSN: 0973-6883
DOI: 10.1016/s0973-6883(12)60087-5